Which of the following is NOT an example of a Type I hypersensitivity reaction?

A Type I hypersensitivity reaction, also known as an immediate hypersensitivity reaction, is an allergic response mediated by IgE antibodies. This type of reaction occurs rapidly, often within minutes of exposure to an allergen, and is characterized by the release of histamine and other mediators from mast cells and basophils.

Urticaria, anaphylactic shock, and allergic rhinitis are all examples of Type I hypersensitivity reactions. Urticaria, commonly known as hives, occurs quickly in response to allergens causing localized swelling and redness. Anaphylactic shock is a severe and potentially life-threatening reaction that can occur after exposure to allergens such as certain foods or insect stings, resulting in widespread vasodilation and airway constriction. Allergic rhinitis, or hay fever, involves an IgE-mediated response to pollen or other airborne allergens, leading to symptoms like sneezing and nasal congestion.

In contrast, contact dermatitis is primarily a Type IV hypersensitivity reaction, which is delayed and is mediated by T cells rather than antibodies. This reaction typically manifests 24 to 48 hours after exposure to a sensitizing agent, such as poison ivy or certain metals. The immune response in this case involves the activation of T lymphocytes, leading